131 companies, compiled from public sources and verified against each company's own site. 7 further entries are held back pending verification.
Being listed is not a claim of membership, endorsement or partnership. To correct or remove an entry, write to [email protected].
RNA interference (RNAi) medicines engineered to cross the blood-brain barrier and systemically deliver gene-silencing to the CNS, via an antibody-oligo conjugate (AOC) brain-shuttle platform; targets genetic forms of Alzheimer's and Parkinson's.
Builds Digit humanoid robots and Arc fleet software for warehouses and factories, with live commercial deployments.
De novo miniprotein therapeutics designed entirely from first principles using generative AI, synthetic biology and robotics; modular miniproteins for targeted delivery and multispecific mechanisms.
Non-profit institute releasing truly open LLMs (OLMo), multimodal models (Molmo), and the full pretraining data/code behind them.
Decentralised compute marketplace where independent providers bid to host containerised CPU/GPU workloads.
Sovereign Specialized LLMs (PhariaAI platform, Kolibri model) built and run on customer-controlled European infrastructure.
Photonic AI inference accelerator (JEF) combining analog and digital electronics with silicon photonics and free-space optics
Nonprofit research institute building AI models of cells and genomes for biology
Permanent, decentralised data-storage protocol with pay-once, store-forever economics.
Integrated cells, genes and software platform for genetic design and advanced-therapy manufacturing
Connectivity silicon for PCIe, CXL and Ethernet enabling rack-scale AI (CXL memory expansion, retimers, switches).
Direct Atomic Layer Processing (DALP) for true atomic-scale additive manufacturing; ships NANOFABRICATOR Lite/PRO systems that build materials and devices atom-by-atom for microelectronics, photonics, quantum and space applications.
Builds gate-based neutral-atom quantum computers scaling toward fault-tolerant, logical-qubit systems.
Proprietary advanced composite manufacturing (precision fiber-to-resin ratio control, low porosity) for aerospace, hypersonic and ballistic parts, including micrometeorite/orbital-debris shielding.
Implantable brain-computer interfaces built on the company's soft 'Fleuron' material; bidirectional neural probes that fit a 2 mm burr hole, plus an in-development Brain Foundation Model for neural signal decoding.
Generative AI + physics ('Intelligent Architecture') platform for computational protein/enzyme design; delivers designed enzymes and enzyme-optimization services (e.g. LYNX) to industrial and life-science partners.
Intracortical electrode arrays (Utah Array) and neural-interface hardware for research and neuroprosthetics
All-analog AI compute (AMPL neural signal processors/chiplets) delivering ultra-low-power, low-latency always-on edge inference in standard CMOS
Builds Projection Micro Stereolithography 3D printers that make micron-scale parts for medical, optical and electronics use.
Sells Akida neuromorphic processor IP, chips and development kits for ultra-low-power edge AI inference.
Academic research consortium developing and testing intracortical BCI for people with paralysis
Nonprofit biomedical research institute focused solely on the biology of aging
ChefOS embodied-AI platform plus robot arms for high-speed food assembly and manipulation, delivered as Robotics-as-a-Service.
Provides a hardware-agnostic quantum software platform (compiler, IDE and OS) that synthesises circuits from high-level functional models.
Enterprise LLMs (Command, Embed, Rerank) and the North agentic platform deployable on-premises, air-gapped or in a customer VPC.
Evaluation platform for voice AI: simulation, observability and labelling so enterprises can test and monitor autonomous voice agents at production scale.
AI software for protein engineering that helps scientists design and optimize proteins with fewer experiments
High-speed SerDes, active electrical cables and connectivity silicon for AI data-centre networks.
Open-source Python framework for orchestrating role-based multi-agent workflows, with an enterprise build-and-runtime control plane.
Digital in-memory compute (memory-centric) chips optimised for AI inference.
Persistent compute for AI agents: "Dedalus Machines" gives agents isolated computers that keep files/state across sessions; unifying SDK across models and MCP servers.
Manufactures Galvorn carbon-nanotube yarns, tapes and wires as a lighter, stronger alternative to copper conductors.
Open-source sandboxed cloud environments for AI agents: secure isolated VMs with code execution, browser use and file systems deployable inside customer clouds.
Open-source confidential-computing stack: Constellation (confidential Kubernetes orchestration), EdgelessDB, EGo/Marblerun; confidential AI (Privatemode); keep data encrypted at runtime in TEEs.
Open-source local-first sync layer (Electric) for Postgres: bidirectional active-active replication to SQLite/IndexedDB clients so apps work offline; Apache-2.0 and designed for self-host to avoid lock-in.
Non-profit lab building open training corpora, training frameworks, and open-weight model suites plus open-weight safety research.
Analog in-memory computing chips for energy-efficient AI inference.
Compute-over-data platform running Docker/WASM jobs where the data lives; open-source Bacalhau.
Compact, modular semiconductor fabs plus self-built lithography/process tools ('a fab that makes fabs') for rapid prototype-scale chip fabrication.
Decentralised storage network turning cloud storage into a cryptographic-proof market; the IPFS incentive layer.
Framework and platform for federated AI that trains models on distributed data without centralising it.
DePIN 'cloudless' compute platform offering decentralised CPU/GPU virtual servers with verifiable execution.
Nonprofit research institute advancing molecular nanotechnology and atomically precise manufacturing via prizes, grants and seminars.
Sells atomic layer deposition equipment and Atomic Armor coatings that build films one atomic layer at a time.
Induced-proximity medicines: a mechanism-agnostic proximity discovery platform (OmniTAC) that modulates 'effector' proteins to drug previously undruggable targets, across oncology, cardiometabolic disease, neurodegeneration and longevity.
Decentralised protocol for verifiable machine-learning compute and training across untrusted hardware.
Superconducting optoelectronic neuromorphic AI hardware - cryogenic, light-linked neural architecture for AI and HPC
Produces SCC55 silicon-carbon composite anode material for lithium-ion batteries at commercial scale.
Community-deployed wireless network for IoT and mobile/Wi-Fi connectivity, rewarded in HNT.
CVD-grown ultra-high-quality single-crystal diamond wafers with proprietary boron and nitrogen doping for quantum processors, power electronics and next-gen sensors.
Closed-loop, AI-guided enzyme engineering ('Digital Enzyme Evolution'): quantum physics-based simulation predicts enzyme variants, task-specific AI models guide design, and robotic labs generate feedback data to improve enzymes for pharma, life sciences and industrial biotech.
Unified retrieval layer for AI agents: full-text (BM25), vector, and SQL search over a single copy of data in Apache Parquet on object storage.
Builds Pulsar, a spiking-neural-network microcontroller for always-on sensor-edge AI at sub-milliwatt power.
Neuromorphic spiking neural network processor (T1) for ultra-low-power, latency-critical sensor and edge AI
Decentralised GPU cloud aggregating idle GPUs into clusters for AI training and inference.
Builds full-stack superconducting quantum computers for on-premises and cloud use by HPC centres, labs and enterprises.
AI-powered motion-planning software (sub-1ms real-time collision-free trajectories) plus the Jacobi Palletizer, enabling industrial-robot deployment in under a day.
Longevity biotech using the RESET platform (large-scale human data + ML) to identify transcription-factor drivers of cell damage and repress them with siRNA 'cell reset therapeutics'; lead programs in obesity and Type 2 diabetes.
Neutral helium atom-beam (BEUV) lithography for maskless, atomically precise chip patterning beyond EUV limits, using a ~0.1 nm-wide atom beam.
Open-source agent frameworks (LangChain, LangGraph) plus the LangSmith platform for agent observability, evaluation and deployment.
Nonprofit funding and research in geroscience to prevent and treat age-related disease
Photonic interconnect fabric and photonic compute for AI data-centre systems.
Efficiency-first, non-transformer foundation models (LFMs) built to run on-device on CPU, GPU or NPU, on or off the cloud.
Not-for-profit open-source silicon: OpenTitan (first open-source silicon root of trust, in production in Google Chromebooks/datacentres), Ibex RISC-V core, CHERIoT; transparent, auditable hardware supply chain.
Coherent optical interconnects (CohZero) for AI-scale data center links, delivering coherent-class performance within IMDD power/cost envelopes
Open-source ML compiler that auto-generates optimized CUDA kernels (a drop-in PyTorch upgrade) to speed model inference and cut GPU cost on any hardware.
TypeScript agent framework with agent/workflow primitives, tool calling, memory, evals and tracing for shipping AI agents to production.
Designs and fabricates metalens metasurface optics on semiconductor foundry lines for 3D sensing and face authentication.
DRAM, HBM and NAND flash producer spanning memory and storage for AI and data-centre systems.
European open-weight frontier models (Mistral Large/Small, Magistral) sold full-stack for enterprise and government sovereignty.
Fully open-source-hardware laptops/desktops (MNT Reform, Pocket Reform, Reform Next, MNT Station); all electronics, firmware, mechanical designs and manuals released (CERN-OHL), modular and repairable, Debian/mainline.
Nanolaser-powered photonic interposers (NConnect) enabling on-package optical interconnect for AI chips, breaking the copper wall
European-anchored full-stack AI cloud with Token Factory serving 60+ open models on owned EU/US data centers with data residency.
Open-source WireGuard-based zero-trust overlay/mesh network; self-hostable coordination plane (Management/Signal/Relay) or managed SaaS; peer-to-peer encrypted tunnels.
Noninvasive BCI ('Neurable AI') — compact brain-signal processing embedded into everyday wearables/headphones; provides real-time cognitive state, focus and mental-fatigue insights.
Epigenetic reprogramming medicines to restore youthful function in aged cells
Open-weight LLMs (Hermes) and the open-source, self-hostable Hermes Agent harness that lets users control where it runs and which models it uses.
Volunteer-run, community-owned wireless mesh network (nonprofit) in New York City; 2,000+ active nodes; governance via the Network Commons License; users own and extend the infrastructure.
Privacy mixnet overlay: packet mixing + timing obfuscation to defeat metadata surveillance; node-incentivised, fully decentralised, open-source.
Self-hosted runtime that runs open-weight models locally in one command on your own hardware, with optional cloud for larger models.
Confidential-computing platform for multi-party analytics and AI/ML inside TEEs; commercialises the open-source MC2 project from UC Berkeley RiseLab; end-to-end protection of data in use.
Inference engine for heterogeneous, self-hosted compute: disaggregates AI workloads across CPUs/GPUs/NPUs on-prem and air-gapped, drop-in for LangChain/Ollama/vLLM.
High-data-rate intracortical BCI platform (Connexus) for restoring speech and communication
Develops generalist robot foundation models that control many robot bodies to perform real manipulation tasks.
Integrated nonlinear photonic devices and circuits - a scalable nonlinear photonics platform for computing, communications and quantum
Formal-verification layer for AI: converts regulation/statutes/clinical rules into LEAN code and returns machine-checkable proofs, refusing answers it cannot prove.
Thin-film cortical electrode array (Layer 7) placed on the brain surface without open-brain surgery
Microalgae-driven photosynthetic biocementation producing zero-carbon bio-cement, masonry units and precast building materials.
Builds quantum control infrastructure software for automated error suppression (Fire Opal) and quantum sensing/navigation.
Builds neutral-atom quantum computers (analog and gate-based) aimed at fault-tolerant quantum computing.
Quantum-dot frequency-comb laser light sources and optical components for scalable AI data center interconnects
GCRAM granular-capacitor on-chip memory IP - drop-in SRAM replacement to ease the AI-chip memory bottleneck (up to 50% area, 10x lower power)
Decentralised GPU rendering and compute network pairing creators and AI workloads with idle GPUs.
Longevity therapeutics via microglia/plasma-inspired approaches, tissue reprogramming and chemical rejuvenation
General-purpose RISC-V zkVM producing cryptographic receipts of program execution (verifiable computation); Bonsai proving platform; ZK-powered apps in Rust/C++.
Provides a quantum error correction stack - decoders, QEC chips and software (Deltaflow) - for fault-tolerant quantum computers.
Photonic/optical switches enabling all-optical networking between AI compute nodes with high bandwidth and low power
Computational protein-design software (ScalaOS) combining atomistic physics, evolutionary data and AI to optimize enzymes, antibodies, therapeutic proteins and antigens in a single design round.
Oxford techbio company taking a 'biology-first' approach to discover disease-modifying drugs that modulate transcription-factor activity; initial focus on neurodegeneration (Alzheimer's, Parkinson's, ALS).
Web-search infrastructure built from scratch for AI agents: own crawlers, index, retrieval and ranking models; deployable on-prem or in private cloud.
Contract manufacturer using Area Printing, a laser metal additive process that prints a whole layer per pulse.
Builds dexterous humanoid robot hands and teleoperation systems with tactile sensing for manipulation research and AI training.
Manufactures silicon-carbon anode material (Titan Silicon) that replaces graphite in lithium-ion cells.
HBM and DRAM producer supplying high-bandwidth memory stacked alongside AI accelerators.
Superconducting (Josephson junction / niobium-titanium nitride) logic compute platform for AI, quantum and HPC data centers
High-density QLC NAND SSDs positioned as HDD replacements for AI and data-centre storage.
Silicon nitride microcomb photonic chips that replace racks of discrete lasers in co-packaged optics for AI data center interconnects
Builds SpiNNaker2 brain-inspired supercomputers for energy-efficient large-scale AI inference.
Nonprofit building OCapN (Object Capability Network) and Goblins: capability-based secure peer-to-peer protocol for sovereign distributed applications where users run their own nodes and control their own data; interoperable with Tor/libp2p.
StartOS sovereign personal-server operating system plus plug-and-play servers; one-click self-hosted open-source services (Bitcoin/Lightning, messaging, files, passwords, Tor) without trusting a cloud provider.
Distributed S3-compatible cloud storage spread across a global network of independent nodes.
Non-surgical, nanoparticle-based bidirectional brain-computer interface ('NanoBCI'): biocompatible nanoparticles delivered intranasally act as antennas to read and write neural signals via a wearable headset; first target is neurological disease treatment.
Aerosol Impact Driven Assembly (AIDA) nanoparticle thin-film coatings and SC510 deposition systems for space/terrestrial solar panels and semiconductors.
Neural-symbolic research lab applying category theory and type theory to build a symbolic reasoning engine and the open-source Agentica SDK.
Endovascular brain-computer interface (Stentrode) delivered through a blood vessel, no open-brain surgery
Develops neuromorphic processor chips for edge vision, sensing and brain-computer interfaces (Speck, Xylo, Rigi, event cameras).
Caching-accelerated inference optimization; KV-cache reuse platform (from the LMCache team) that eliminates redundant GPU recomputation for enterprise LLM/agent workloads.
Decentralised indexing and querying of blockchain data via Subgraphs and Substreams.
Formal program verification for AI-generated code: trains models to auto-generate proofs and builds verified sandboxes agents cannot escape or game.
AI-native hybrid search engine for enterprises — vector search, keyword matching, filtering and custom ranking in a single query for apps and agents.
Observability and automated evaluation for AI agents; commercial platform built on the open-source OpenLLMetry SDK to catch agent failures in production.
umbrelOS personal-server operating system and Umbrel Home plug-and-play server for self-hosting apps (Nextcloud, Matrix, PhotoPrism, Bitcoin/Lightning nodes); one-click de-clouding of personal data.
CXL/UALink Memory-over-Fabrics pooling, sharing and tiering (MAX) to extend memory beyond GPU HBM for AI and HPC
Onshore production of sintered NdFeB (neodymium-iron-boron) high-performance rare-earth permanent magnets.
ReRAM (resistive RAM) silicon-oxide non-volatile memory IP for embedded and storage-class applications.
xCognition cognitive-control AI that self-programs industrial robots and CNC machines (with PLCfy), generating robot and PLC code with zero manual programming.
Develops photonic quantum computers and the open-source PennyLane quantum software library for quantum computing and machine learning.
Volunteer-run, copyleft self-hosting server OS (Debian-based) with 500+ packaged self-hostable apps, web admin, SSO, mail and XMPP; democratise self-hosting for non-technical users.
Developer-first retrieval infrastructure ("Supabase for search"): API managing ingestion, indexing, reranking and evaluation; proprietary ze-rank-1 reranker.
Builds atomically precise manufacturing tools: STM-based lithography that patterns single atoms at sub-nanometre resolution.